https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41782 0.05). Our findings suggest that the inverse association of birthweight with hypertension risk from observational studies was not supported by large Mendelian randomization analyses.]]> Wed 22 Mar 2023 14:30:25 AEDT ]]> Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:56207 Tue 13 Aug 2024 14:48:33 AEST ]]> A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46943 METTL15). The variant was nominally associated with only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than 10 single nucleotide polymorphisms (SNPs) (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.]]> Fri 09 Dec 2022 14:01:32 AEDT ]]>